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In Bios: Genesis, 1 to 4 Players start as organic compounds shortly after Earth's formation, represented by up to 3 Biont Tokens. The Amino Acids command Metabolism, the lipids create cells, the pigments control energy absorption and storage, and the nucleic acids control templated replication. Their goal is a double origin of life: first as Autocatalytic Life (a metabolic cycle reproducing, yet not replicating, its own constituents), and the second as Darwinian Life (an Organism using a template to replicate in an RNA World). Players can play Cooperative, Competitive or Solitaire.
Notes designer Phil Eklund, "This subject is the most difficult and ambitious I have ever attempted and it has taken many years to get it to work right." With Bios: Genesis, Bios: Megafauna, and Origins: How We Became Human, Eklund takes players through almost the whole breadth and scope of life on Earth.